Research Associate in Cardiovascular and Metabolic Disease Models in vitro_2 years temporary

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La position In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. pRED Cardiovascular & Metabolism, Immunology (CMI), located in Basel, Switzerland, focuses on the discovery and early development of innovative treatments for specific diseases that affect the lives of millions.

In the cardiovascular and metabolism area, we are developing cutting-edge therapies to treat metabolic diseases. We are seeking an experienced Research Associate with a strong industry background to join our Cardiovascular and Metabolic Diseases (CVM) in vitro department. In this role, you will design and execute in-vitro experiments using complex cellular models to evaluate the efficacy and safety of novel therapeutic candidates for cardiovascular and metabolic diseases. The opportunity

• Cultivation of primary cell lines from human and animal tissues, optimizing protocols for primary cell isolation, differentiation and maintenance.
• Execution of functional cell based and enzymatic assays to study metabolic pathways and other relevant metabolic pathways related readouts e.g. lipolysis, glucose uptake, cAMP signaling
• Experience in advanced cellular and biochemical techniques, such as cell painting, and metabolic flux analysis using Seahorse to evaluate cellular bioenergetics.
• Strong knowledge of standard molecular biology techniques such as qPCR, Western Blot, Immunohistochemistry.
• Analyze experimental data with statistical tools, preparing high-quality reports and presentations to communicate findings effectively.
• Experience with animal handling, treatment and functional metabolic experimentation is advantageous Who you are:
• You hold a Bachelor’s or Master’s degree in biology, biochemistry, or a related field, or have completed vocational training in biology. A minimum of 3 years in a pharma industry laboratory setting is required.
• You are proficient in cell culture, molecular biology, and biochemical techniques and are familiar with metabolic and/or cardiovascular cellular models.
• You communicate effectively in English, both in writing and orally. Skillfully able to interact with people and have strong commitment to teamwork.
• Strong organizational skills, excellent data management and record-keeping skills are required. At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you. Qui nous sommes Un avenir plus sain nous pousse à innover. Ensemble, plus de 100 000 employés à travers le monde sont dédiés à faire progresser la science et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir. Nos efforts aboutissent à plus de 26 millions de personnes traitées avec nos médicaments et plus de 30 milliards de tests réalisés avec nos produits de Diagnostique. Nous nous encourageons mutuellement à explorer de nouvelles possibilités, à favoriser la créativité et à conserver nos grandes ambitions, afin de fournir des solutions de santé qui changent des vies et ont un impact mondial. Construisons ensemble un avenir plus sain. Roche est un employeur offrant l'équité en matière d'emploi.