AI research intern: biological clock analysis

About

Biolevate builds AI-powered software that turns unstructured scientific data into reliable, collaborative workflows for medical writing and regulatory work. Our platform helps scientists, clinicians and medical writers move faster while maintaining the rigor their work demands.

Founded in Paris in 2024, we combine a commercial SaaS platform with in-house research in oncology and dermatology. It is an unusually practical place to work on AI: the systems we build are used both to advance scientific research and to help bring therapies to patients faster.

Biolevate Science team

At Biolevate, the Science team is building a new way to think about biology. We start from a simple conviction: disease is not random chaos, but a biological language - a logic of how life adapts, resists, and reorganises under pressure. Our scientists use advanced multi-omics reasoning to listen to this language across genes, RNAs, proteins, pathways, and clinical context, and to reconstruct the rules that drive health and disease.

Rather than generating ever more lists of genes, we work to integrate diverse biological layers into coherent programs and convert them into testable, traceable hypotheses. This helps us identify mechanistic patient subgroups, uncover hidden regulators of response and resistance, and prioritise therapeutic targets with a clear biological rationale. Along the way, we rely on platforms like OCEAN to support a more explicit and structured way of reasoning through complex biology.

The goal is always to close the loop: we design experiments, validate hypotheses in cellular and ex vivo models, and translate what we learn into patents, biomarkers, new targets, and smarter trial strategies. In practice, this means moving from data to decisions - using evidence that is mechanistically grounded, auditable , and strong enough to support real R&D choices.

Within a few years, this approach has already contributed to a growing patent portfolio, redefined disease logic in oncology, and uncovered patient categories invisible to genetics alone. At Biolevate, scientists remain in control of meaning while AI expands their capacity to explore, explain, and anticipate biology’s logic. Together, we are building a shared intelligence of biology - one that connects discovery to real clinical impact for patients.

Context Recent clinical evidence suggests that treatment timing may influence immunotherapy efficacy , highlighting the role of circadian regulation in transcriptional, metabolic, and immune processes. The internship aims to integrate this temporal dimension into multi-omics and patient stratification , using AI to characterize circadian states and investigate whether molecular information measured at one time point can inform treatment opportunities at other, unobserved times. Internship goals

• Integrate circadian biology into multi-omics analyses
• Curate circadian gene signatures and integrate them into existing pathway-analysis pipelines.

- Assess their robustness across cancer types and public datasets.

• Develop circadian state metrics
• Build metrics describing circadian phase, synchronization, disruption, and rhythmicity from transcriptomic and multi-omics profiles.

- Explore ML approaches for inferring latent circadian states, including from single-time-point measurements.

• Investigate circadian-aware treatment stratification
• Identify molecular circadian dysregulation and relevant patient subgroups.

- Assess whether circadian information improves treatment-response stratification alongside immune, metabolic, and clinical features.

- Investigate the prediction of time-dependent therapeutic sensitivity and candidate treatment windows .

• Model unobserved circadian states
• Train diffusion models, JEPA-like architectures, and/or other temporal models to learn how molecular states evolve across circadian time.

- Investigate whether a profile measured at one time point can be used to infer plausible molecular states at unobserved time points .

- Use these inferred states to assess whether treatment may be more favorable at another circadian phase.

- Validate predictions on time-resolved datasets and quantify uncertainty.

• Develop a circadian-aware AI prototype
• Integrate circadian metrics, temporal models, and treatment stratification into a modular computational pipeline.

- Demonstrate the approach on relevant clinical or public datasets as a proof of concept for AI-driven chronotherapy and precision medicine .

Why Biolevate

• Meaningful mission: We are building a new way to understand biology - one that treats disease as a causal, mechanistic system rather than a collection of disconnected signals. As a researcher at Biolevate, your work helps turn complex biological data into clearer hypotheses, sharper questions, and more relevant scientific insight.
• Scientific impact: Your research will contribute directly to the discovery of mechanistic patient subgroups, actionable targets, biomarkers, and smarter trial strategies. The work is not theoretical for its own sake: it is designed to move from biological signal to meaningful scientific and clinical decisions.
• Deep biological reasoning: You will work with a platform built to integrate multi-layer evidence across omics, pathways, network logic, literature, and pharmacology. That means less time spent navigating fragmented data and more time uncovering true drivers, hidden regulators, resistance mechanisms, and the biological context that gives results meaning.
• Rigor and traceability: Biolevate is a place for researchers who care about evidence quality. We value explicit reasoning, ranked evidence, auditable logic, and testable hypotheses - so the science is not only insightful, but defensible and reproducible.
• Close collaboration and partnership: Research here does not stop at analysis. We work in close partnership with internal teams and external collaborators to turn biological insight into shared next steps, aligned interpretation, and stronger scientific decisions. That creates a true loop between computation, biology, and collective problem-solving.
• Ownership and growth: You will have the opportunity to shape how new biology is discovered and interpreted, with room to influence methods, standards, and scientific direction as the company grows.
• Paris-based deeptech environment: Join a team working at the intersection of biology, data, and decision intelligence in a strong French deeptech ecosystem - with the ambition to create tools and insights that matter globally.

Biolevate

We value authenticity and benevolence . Every team member contributes their unique background and life journey, which makes us a stronger collective. Beyond work, we genuinely enjoy spending time together, team dinners, weekend treks, sport sessions, offsites, and many shared experiences that build strong bonds.

At Biolevate, you will be part of a dynamic, international team shaping the future of drug discovery and medical innovation. We combine deep science, cutting-edge AI, and internal research to deliver real-world impact. Join us to build a global brand with purpose and grow in a high-trust, high-growth environment with a compelling package that includes stock options.

• 💼 Attractive Financial Package: We offer a compelling package, which includes a competitive salary and stock options, that recognizes your skills and experience, ensuring you feel valued for your contributions to our innovative projects.
• 📍Private Office: Station F , the world’s largest startup campus, in Paris.
• 🏡 Flexible Work Arrangements: We support work-life balance with flexible working hours and options for remote or hybrid work arrangements, understanding the value of flexibility in today's dynamic world.
• 🌎 Collaborative & International Culture: Experience a positive, inclusive, and collaborative work environment. We value each team member’s contribution and encourage sharing ideas and feedback.
• 🤝 Authentic Team Culture: We value authenticity and benevolence. Our diverse background make us stronger, and we enjoy building real connections through team moments like dinners, sport sessions, offsites, and shared experiences.
• 🍽️ 💻 Other perks : Meal vouchers, Latest Macbook and tech

Interview Process

can be adapted when needed, but generally includes the following steps :

• First screening interview (visio)
• Meet the Biolevate team at Station F and meet founders
• Internal review
• Offer